HPK1 Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of JUN kinase activity; activation of protein kinase activity; cell proliferation; cellular response to phorbol 13-acetate 12-myristate; intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  P70218 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; Hpk1; M4K1; Map4k1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbols: Map4k1
Molecular weight: 91,535 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HPK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene