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UBE2J1
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 5q21 |
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Cellular Component:
integral component of membrane
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Molecular Function:
ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding
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Biological Process:
negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of tumor necrosis factor biosynthetic process; spermatid development; ubiquitin-dependent ERAD pathway
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Reference #:
NP_001100112
(RefSeq)
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Alt. Names/Synonyms: Ube2j1; ubiquitin-conjugating enzyme E2, J1
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Gene Symbols: Ube2j1
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Molecular weight:
27,880 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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