UBE2J1 Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 5q21
Cellular Component:  integral component of membrane
Molecular Function:  ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding
Biological Process:  negative regulation of retrograde protein transport, ER to cytosol; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of tumor necrosis factor biosynthetic process; spermatid development; ubiquitin-dependent ERAD pathway
Reference #:  NP_001100112 (RefSeq)
Alt. Names/Synonyms: Ube2j1; ubiquitin-conjugating enzyme E2, J1
Gene Symbols: Ube2j1
Molecular weight: 27,880 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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UBE2J1

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  ENZYME  |  Entrez-Gene  |  GenPept