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GRB10
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. Belongs to the GRB7/10/14 family. Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 11 A1|11 7.15 cM |
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Cellular Component:
cytoplasm; cytosol; protein-containing complex
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Molecular Function:
identical protein binding; insulin receptor binding; phosphotyrosine residue binding; protein binding; protein-macromolecule adaptor activity; signaling receptor complex adaptor activity
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Biological Process:
ERK1 and ERK2 cascade; gene expression; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of Wnt signaling pathway; positive regulation of cold-induced thermogenesis; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin; signal transduction; vascular associated smooth muscle cell migration
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Reference #:
Q60760
(UniProtKB)
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Alt. Names/Synonyms: 5730571D09Rik; AI325020; Grb10; GRB10 adapter protein; growth factor receptor bound protein 10; Growth factor receptor-bound protein 10; maternally expressed gene 1; Maternally expressed gene 1 protein; Meg1; mKIAA0207; OTTMUSP00000005375
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Gene Symbols: Grb10
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Molecular weight:
70,585 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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