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HMGA2
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Belongs to the HMGA family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 10 D2|10 67.94 cM |
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Cellular Component:
chromatin; male germ cell nucleus; nuclear chromosome; nucleus; protein-DNA complex; senescence-associated heterochromatin focus; SMAD protein complex
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Molecular Function:
5'-deoxyribose-5-phosphate lyase activity; C2H2 zinc finger domain binding; cAMP response element binding; DNA binding; DNA binding, bending; DNA-(apurinic or apyrimidinic site) endonuclease activity; DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding; MH1 domain binding; MH2 domain binding; minor groove of adenine-thymine-rich DNA binding; nucleic acid binding; nucleosomal DNA binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription cis-regulatory region binding; transcription coregulator activity; transcription corepressor activity
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Biological Process:
adipose tissue development; adrenal gland development; astrocyte differentiation; base-excision repair; cell cycle; cell division; cell population proliferation; cell proliferation in forebrain; chondrocyte differentiation; chondrocyte proliferation; chromosome condensation; endodermal cell differentiation; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fat cell differentiation; fat pad development; fibroblast proliferation; heterochromatin formation; intracellular signal transduction; lung epithelium development; male gonad development; meiotic cell cycle; mesenchymal cell differentiation; mesodermal cell differentiation; mesodermal-endodermal cell signaling; multicellular organism growth; negative regulation by host of viral transcription; negative regulation of apoptotic process; negative regulation of astrocyte differentiation; negative regulation of cellular senescence; negative regulation of DNA binding; negative regulation of DNA-templated transcription; negative regulation of double-strand break repair via nonhomologous end joining; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; oncogene-induced cell senescence; pituitary gland development; positive regulation of angiogenesis; positive regulation of cell population proliferation; positive regulation of cell proliferation in bone marrow; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein serine/threonine kinase activity; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of growth hormone secretion; regulation of peptide hormone secretion; regulation of stem cell population maintenance; somatic stem cell population maintenance; spermatogenesis; stem cell proliferation
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Reference #:
P52927
(UniProtKB)
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Alt. Names/Synonyms: 9430083A20Rik; high mobility group AT-hook 2; High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high mobility group protein I; high mobility group protein I, isoform C; Hmga2; Hmgi; HMGI-; HMGI-C; Hmgic; MGC103393; pg; pygmy
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Gene Symbols: Hmga2
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Molecular weight:
11,819 Da
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Basal Isoelectric point:
10.63
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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