GRB2 an adaptor protein of the GRB2 / sem-5 / DRK family. Associates with many different tyrosine-phosphorylated proteins via its SH2 domain, including EGFR, PDGFR, IRS-1, SHC and LNK. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Four alternatively spliced isoforms have been described. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 E2|11 80.91 cM
Cellular Component:  cell-cell junction; COP9 signalosome; cytoplasm; endosome; Golgi apparatus; Grb2-EGFR complex; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; vesicle membrane
Molecular Function:  enzyme binding; ephrin receptor binding; epidermal growth factor receptor binding; identical protein binding; insulin receptor substrate binding; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process:  aging; anatomical structure formation involved in morphogenesis; branching involved in labyrinthine layer morphogenesis; cell differentiation; cellular response to ionizing radiation; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of reactive oxygen species metabolic process; protein heterooligomerization; Ras protein signal transduction; receptor internalization; regulation of MAPK cascade; signal transduction in response to DNA damage
Reference #:  Q60631 (UniProtKB)
Alt. Names/Synonyms: AA408164; Adapter protein GRB2; Ash; Grb2; growth factor receptor bound protein 2; Growth factor receptor-bound protein 2; OTTMUSP00000003660; OTTMUSP00000003661; RP23-28I4.1; SH2/SH3 adapter GRB2
Gene Symbols: Grb2
Molecular weight: 25,238 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene