GRB2 Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Belongs to the GRB2/sem-5/DRK family. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 11 E2|11 80.91 cM
Cellular Component:  cell-cell junction; COP9 signalosome; cytoplasm; cytosol; endosome; Golgi apparatus; Grb2-EGFR complex; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane; protein-containing complex; vesicle membrane
Molecular Function:  enzyme binding; ephrin receptor binding; epidermal growth factor receptor binding; guanyl-nucleotide exchange factor adaptor activity; identical protein binding; insulin receptor substrate binding; molecular adaptor activity; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; protein-macromolecule adaptor activity; SH3 domain binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  actin cytoskeleton organization; anatomical structure formation involved in morphogenesis; B cell receptor signaling pathway; branching involved in labyrinthine layer morphogenesis; cellular response to ionizing radiation; endodermal cell differentiation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; positive regulation of actin filament polymerization; positive regulation of reactive oxygen species metabolic process; Ras protein signal transduction; receptor internalization; regulation of MAPK cascade; signal transduction; signal transduction in response to DNA damage
Reference #:  Q60631 (UniProtKB)
Alt. Names/Synonyms: AA408164; Adapter protein GRB2; Ash; Grb2; growth factor receptor bound protein 2; Growth factor receptor-bound protein 2; OTTMUSP00000003660; OTTMUSP00000003661; RP23-28I4.1; SH2/SH3 adapter GRB2
Gene Symbols: Grb2
Molecular weight: 25,238 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene