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EVI2B
Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Strongly expressed in granulocytic cells, and weakly on lymphocytes cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Oncoprotein |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
plasma membrane
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Biological Process:
myeloid cell development; negative regulation of apoptotic process; positive regulation of granulocyte differentiation; positive regulation of neutrophil differentiation; regulation of cell cycle; regulation of stem cell division
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Reference #:
P34910
(UniProtKB)
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Alt. Names/Synonyms: CD361; D17S376; ecotropic viral integration site 2B; Ecotropic viral integration site 2B protein homolog; EVDB; EVI-2B; EVI2B; Protein EVI2B
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Gene Symbols: EVI2B
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Molecular weight:
48,666 Da
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Basal Isoelectric point:
4.67
Predict pI for various phosphorylation states
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