DAK Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response. Belongs to the dihydroxyacetone kinase (DAK) family. Detected in erythrocytes (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; EC; Kinase, other; Lipid Metabolism - glycerolipid
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component:  cytosol
Molecular Function:  ATP binding; FAD-AMP lyase (cyclizing) activity; glycerone kinase activity; metal ion binding; protein binding; triokinase activity
Biological Process:  carbohydrate phosphorylation; cellular carbohydrate metabolic process; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate; innate immune response; negative regulation of MDA-5 signaling pathway; regulation of innate immune response
Disease: Triokinase And Fmn Cyclase Deficiency Syndrome
Reference #:  Q3LXA3 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent dihydroxyacetone kinase; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); DAK; DHA kinase; Dha kinase/FMN cyclase; DHAK; dihydroxyacetone kinase 2 homolog; dihydroxyacetone kinase 2 homolog (S. cerevisiae); DKFZp586B1621; FAD-AMP lyase (cyclic FMN forming); FAD-AMP lyase (cyclizing); FAD-AMP lyase cyclic FMN forming; FAD-AMP lyase cyclizing; FMN cyclase; Glycerone kinase; MGC5621; NET45; testis tissue sperm-binding protein Li 84P; TKFC; TKFCD; Triokinase; triokinase and FMN cyclase; Triokinase/FMN cyclase; Triose kinase
Gene Symbols: TKFC
Molecular weight: 58,947 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene