HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. Belongs to the HMG-CoA reductase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis
Chromosomal Location of Human Ortholog: 2q12
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle; peroxisomal membrane
Molecular Function:  coenzyme binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; hydroxymethylglutaryl-CoA reductase activity; NADPH binding; protein homodimerization activity; protein phosphatase 2A binding
Biological Process:  aging; cholesterol biosynthetic process; coenzyme A metabolic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; myoblast differentiation; negative regulation of amyloid-beta clearance; negative regulation of apoptotic process; negative regulation of blood vessel diameter; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein secretion; negative regulation of striated muscle cell apoptotic process; negative regulation of wound healing; oxidation-reduction process; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of skeletal muscle tissue development; positive regulation of smooth muscle cell proliferation; positive regulation of stress-activated MAPK cascade; protein tetramerization; response to ethanol; response to nutrient; sterol biosynthetic process; ubiquinone metabolic process; visual learning
Reference #:  P51639 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH; HMG-CoA reductase; Hmgcr
Gene Symbols: Hmgcr
Molecular weight: 96,688 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene