GluR2 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q33
Cellular Component:  AMPA glutamate receptor complex; asymmetric synapse; cell junction; cell surface; dendrite; dendrite cytoplasm; dendritic shaft; dendritic spine; endoplasmic reticulum; endoplasmic reticulum membrane; glutamatergic synapse; growth cone; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; ionotropic glutamate receptor complex; membrane; neuron projection; neuronal cell body; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse; somatodendritic compartment; synapse; synaptic membrane; synaptic vesicle; synaptic vesicle membrane; terminal bouton
Molecular Function:  AMPA glutamate receptor activity; amyloid-beta binding; ATPase binding; cytoskeletal protein binding; extracellularly glutamate-gated ion channel activity; identical protein binding; immunoglobulin binding; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; PDZ domain binding; protein binding; protein kinase binding; signaling receptor activity; SNARE binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chemical synaptic transmission; establishment of protein localization; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; positive regulation of synaptic transmission; protein tetramerization; receptor internalization; regulation of postsynaptic membrane potential; regulation of receptor recycling; regulation of synaptic transmission, glutamatergic; response to fungicide; response to lithium ion
Reference #:  P19491 (UniProtKB)
Alt. Names/Synonyms: AMPA-selective glutamate receptor 2; GluR-2; GluR-B; GluR-K2; Glur2; Glutamate receptor 2; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; Gria2
Gene Symbols: Gria2
Molecular weight: 98,688 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene