HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. Belongs to the HMG-CoA reductase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of human Ortholog: 5q13.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; peroxisomal membrane

Molecular Function: coenzyme A binding; GTPase regulator activity; hydroxymethylglutaryl-CoA reductase (NADPH) activity; NADPH binding; protein binding

Biological Process: cholesterol biosynthetic process; coenzyme A metabolic process; isoprenoid biosynthetic process; long-term synaptic potentiation; negative regulation of amyloid-beta clearance; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein secretion; regulation of ERK1 and ERK2 cascade; sterol biosynthetic process; visual learning

Disease: Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 3; Myopathy, Limb-girdle, Adult-onset

Reference #: P04035 (UniProtKB)

Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG-CoA reductase; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3

Gene Symbols: HMGCR

Molecular weight: 97,476 Da

Basal Isoelectric point: 6.33 Predict pI for various phosphorylation states

CST Pathways: AMPK Signaling

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HMGCR

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