HMGCR Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. Belongs to the HMG-CoA reductase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis
Chromosomal Location of human Ortholog: 5q13.3
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; peroxisomal membrane
Molecular Function:  coenzyme A binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; NADPH binding; protein binding
Biological Process:  cholesterol biosynthetic process; coenzyme A metabolic process; isoprenoid biosynthetic process; negative regulation of amyloid-beta clearance; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein secretion; sterol biosynthetic process; visual learning
Reference #:  P04035 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG-CoA reductase; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3
Gene Symbols: HMGCR
Molecular weight: 97,476 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein