GBP1 iso2 a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Hydrolase; Vesicle
Chromosomal Location of Human Ortholog: 3 H1|3 66.69 cM
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; extracellular region; Golgi apparatus; membrane; plasma membrane; symbiont-containing vacuole membrane
Molecular Function:  GMP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein homodimerization activity
Biological Process:  adhesion of symbiont to host; cellular response to interferon-beta; cellular response to interferon-gamma; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; immune system process
Reference #:  A4UUI2 (UniProtKB)
Alt. Names/Synonyms: 5830475C06; GBP-1; Gbp1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; Guanylate binding protein 1; guanylate nucleotide binding protein 1; Interferon-gamma-inducible protein MAG-1; Interferon-induced guanylate-binding protein 1; Mag-1; mGBP-1; mGBP1; MGC124334; Mpa-1; Mpa1
Gene Symbols: Gbp2b
Molecular weight: 67,841 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

GBP1 iso2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein