GBP1 iso2 Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Hydrolase; Vesicle
Chromosomal Location of Human Ortholog: 3 H1|3 66.69 cM
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; extracellular region; Golgi apparatus; membrane; plasma membrane; symbiont-containing vacuole membrane
Molecular Function:  GMP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein homodimerization activity
Biological Process:  adhesion of symbiont to host; cellular response to interferon-beta; cellular response to interferon-gamma; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; immune system process
Reference #:  A4UUI2 (UniProtKB)
Alt. Names/Synonyms: 5830475C06; GBP-1; Gbp1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; Guanylate binding protein 1; guanylate nucleotide binding protein 1; Interferon-gamma-inducible protein MAG-1; Interferon-induced guanylate-binding protein 1; Mag-1; mGBP-1; mGBP1; MGC124334; Mpa-1; Mpa1
Gene Symbols: Gbp2b
Molecular weight: 67,841 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
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GBP1 iso2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein