BOP1 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the WD repeat BOP1/ERB1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 15 D3|15 35.91 cM
Cellular Component:  nucleolus; nucleus; PeBoW complex; preribosome, large subunit precursor; ribonucleoprotein complex
Molecular Function:  protein binding; ribonucleoprotein complex binding
Biological Process:  cell proliferation; cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of cell cycle; regulation of signal transduction by p53 class mediator; ribosomal large subunit assembly; ribosomal large subunit biogenesis; ribosome biogenesis; rRNA processing
Reference #:  P97452 (UniProtKB)
Alt. Names/Synonyms: AU020183; AW146150; block of proliferation 1; Block of proliferation 1 protein; Bop1; D18861; Erb; Erb1p; Kiaa0124; mKIAA0124; Ribosome biogenesis protein BOP1
Gene Symbols: Bop1
Molecular weight: 82,546 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene