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HMGN1
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. Belongs to the HMGN family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 21q22.2 |
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Cellular Component:
chromatin; cytoplasm; female germ cell nucleus; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA binding; nucleosomal DNA binding; protein binding
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Biological Process:
chromatin organization; positive regulation of DNA-templated transcription, elongation; positive regulation of NAD+ ADP-ribosyltransferase activity; post-embryonic camera-type eye morphogenesis; pyrimidine dimer repair by nucleotide-excision repair; regulation of development, heterochronic; regulation of epithelial cell proliferation; regulation of transcription by RNA polymerase II; response to UV-B; response to UV-C; transcription-coupled nucleotide-excision repair
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Reference #:
P05114
(UniProtKB)
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Alt. Names/Synonyms: FLJ27265; FLJ31471; high mobility group nucleosome binding domain 1; High mobility group nucleosome-binding domain-containing protein 1; high-mobility group (nonhistone chromosomal) protein 14; high-mobility group nucleosome binding 1; high-mobility group nucleosome binding domain 1; HMG14; HMGN1; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; nonhistone chromosomal protein HMG-14
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Gene Symbols: HMGN1
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Molecular weight:
10,659 Da
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Basal Isoelectric point:
9.6
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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