RGS19 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 3q43
Cellular Component:  brush border; clathrin-coated vesicle; cytoplasm; Golgi membrane; membrane; membrane raft
Molecular Function:  G-protein alpha-subunit binding; GTPase activator activity; protein binding
Biological Process:  negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway; response to ethanol
Reference #:  O70521 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase I; Camki; G alpha interacting protein; G-alpha-interacting protein; GAIP; MGC108699; Regulator of G-protein signaling 19; regulator of G-protein signalling 19; RGS19
Gene Symbols: Rgs19
Molecular weight: 24,738 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene