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RGS19
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, RGS |
| Chromosomal Location of Human Ortholog: 3q43 |
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Cellular Component:
brush border; clathrin-coated vesicle; cytoplasm; Golgi membrane; membrane; membrane raft
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Molecular Function:
G-protein alpha-subunit binding; GTPase activator activity; protein binding
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Biological Process:
negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway; response to ethanol
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Reference #:
O70521
(UniProtKB)
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Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase I; Camki; G alpha interacting protein; G-alpha-interacting protein; GAIP; MGC108699; Regulator of G-protein signaling 19; regulator of G-protein signalling 19; RGS19
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Gene Symbols: Rgs19
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Molecular weight:
24,738 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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