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HIRA
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Belongs to the WD repeat HIR1 family. Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Cell development/differentiation; Transcription regulation |
| Chromosomal Location of Human Ortholog: 16 A3|16 11.69 cM |
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Cellular Component:
HIR complex; nuclear chromatin; nucleus; protein-containing complex
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Molecular Function:
protein binding; transcription corepressor activity
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Biological Process:
chromatin organization; chromatin silencing at centromere; DNA replication-independent nucleosome assembly; gastrulation; mitotic sister chromatid segregation; muscle cell differentiation; osteoblast differentiation; regulation of chromatin silencing; regulation of transcription, DNA-templated; transcription, DNA-templated
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Reference #:
Q61666
(UniProtKB)
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Alt. Names/Synonyms: AA138857; D16Ertd95; D16Ertd95e; Gm15797; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; Protein HIRA; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; Tupl; Tuple1
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Gene Symbols: Hira
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Molecular weight:
111,767 Da
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Basal Isoelectric point:
8.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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