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BCL2L10
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Belongs to the Bcl-2 family. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 15q21.2 |
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Cellular Component:
cytosol; endoplasmic reticulum; membrane; mitochondria-associated endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; spindle
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Molecular Function:
calcium ion binding; caspase binding; protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; extrinsic apoptotic signaling pathway in absence of ligand; female gamete generation; intrinsic apoptotic signaling pathway in response to DNA damage; microtubule organizing center organization; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; spermatogenesis
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Reference #:
Q9HD36
(UniProtKB)
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Alt. Names/Synonyms: Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B; B2L10; Bcl-2-like protein 10; BCL-B; BCL2 like 10; Bcl2-L-10; BCL2-like 10 (apoptosis facilitator); BCL2L10; BCLB; Boo; death inducer binding to vBcl-2 and Apaf-1; Diva; MGC129810; MGC129811
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Gene Symbols: BCL2L10
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Molecular weight:
23,204 Da
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Basal Isoelectric point:
9.63
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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