BCL2L10 Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Belongs to the Bcl-2 family. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral
Chromosomal Location of human Ortholog: 15q21.2
Cellular Component:  cytosol; endoplasmic reticulum; membrane; mitochondria-associated endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; spindle
Molecular Function:  calcium ion binding; caspase binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; extrinsic apoptotic signaling pathway in absence of ligand; female gamete generation; intrinsic apoptotic signaling pathway in response to DNA damage; microtubule organizing center organization; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; spermatogenesis
Reference #:  Q9HD36 (UniProtKB)
Alt. Names/Synonyms: Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B; B2L10; Bcl-2-like protein 10; BCL-B; BCL2 like 10; Bcl2-L-10; BCL2-like 10 (apoptosis facilitator); BCL2L10; BCLB; Boo; death inducer binding to vBcl-2 and Apaf-1; Diva; MGC129810; MGC129811
Gene Symbols: BCL2L10
Molecular weight: 23,204 Da
Basal Isoelectric point: 9.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein