PLPB1 Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. Belongs to the MYT1 family. Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding
Biological Process:  cell differentiation; nervous system development; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q01538 (UniProtKB)
Alt. Names/Synonyms: C20orf36; KIAA0835; KIAA1050; MTF1; Myelin transcription factor 1; Myelin transcription factor I; MYT1; MYTI; neural zinc finger transcription factor 2; NZF2; PLPB1; proteolipid protein binding protein; Proteolipid protein-binding protein; ZC2H2C1; ZC2HC4A
Gene Symbols: MYT1
Molecular weight: 122,329 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
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PLPB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene