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JDP2
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Belongs to the bZIP family. ATF subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 14q24.3 |
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Cellular Component:
chromatin; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
cAMP response element binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone chaperone activity; histone deacetylase binding; leucine zipper domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
chromatin remodeling; fat cell differentiation; negative regulation of fat cell differentiation; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Reference #:
Q8WYK2
(UniProtKB)
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Alt. Names/Synonyms: JDP2; Jun dimerization protein 2; JUNDM2; progesterone receptor co-activator
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Gene Symbols: JDP2
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Molecular weight:
18,704 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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