GAB1
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Belongs to the GAB family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 8|8 C2 |
Cellular Component:
cell-cell junction; cytoplasm; cytosol
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Molecular Function:
protein binding; signaling adaptor activity
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Biological Process:
angiogenesis; cellular response to vascular endothelial growth factor stimulus; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; epidermis development; heart development; interleukin-6-mediated signaling pathway; labyrinthine layer development; MAPK cascade; platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; regulation of cell migration; response to hepatocyte growth factor; response to oxidative stress; signal transduction; vascular endothelial growth factor signaling pathway
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Reference #:
Q9QYY0
(UniProtKB)
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Alt. Names/Synonyms: AA408973; AW107238; Gab1; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1
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Gene Symbols: Gab1
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Molecular weight:
76,812 Da
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Basal Isoelectric point:
5.42
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Insulin Receptor Signaling
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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