GAB1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Belongs to the GAB family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 8|8 C2
Cellular Component:  cell-cell junction; cytoplasm; cytosol
Molecular Function:  protein binding; signaling adaptor activity
Biological Process:  angiogenesis; cellular response to vascular endothelial growth factor stimulus; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; epidermis development; heart development; interleukin-6-mediated signaling pathway; labyrinthine layer development; MAPK cascade; platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; regulation of cell migration; response to hepatocyte growth factor; response to oxidative stress; signal transduction; vascular endothelial growth factor signaling pathway
Reference #:  Q9QYY0 (UniProtKB)
Alt. Names/Synonyms: AA408973; AW107238; Gab1; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1
Gene Symbols: Gab1
Molecular weight: 76,812 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GAB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein