G-gamma 12 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the G protein gamma family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component:  actin filament; plasma membrane
Molecular Function:  GTPase activity; PDZ domain binding; phosphate ion binding; protein binding
Biological Process:  cerebral cortex development; response to lipopolysaccharide; signal transduction
Reference #:  Q9UBI6 (UniProtKB)
Alt. Names/Synonyms: FLJ31352; FLJ34695; G protein subunit gamma 12; G-gamma 12; G-protein gamma-12 subunit; GBG12; GNG12; guanine nucleotide binding protein (G protein), gamma 12; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene Symbols: GNG12
Molecular weight: 8,006 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-gamma 12

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene