TICRR
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Belongs to the treslin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; DNA replication |
Chromosomal Location of human Ortholog: 15q26.1 |
Cellular Component:
cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; protein binding
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Biological Process:
DNA repair; DNA replication; mitotic DNA replication checkpoint signaling; mitotic G2 DNA damage checkpoint signaling; regulation of DNA-templated DNA replication initiation; response to ionizing radiation
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Reference #:
Q7Z2Z1
(UniProtKB)
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Alt. Names/Synonyms: C15orf42; chromosome 15 open reading frame 42; FLJ41618; MGC45866; SLD3; TICRR; TOPBP1 interacting checkpoint and replication regulator; TopBP1-interacting checkpoint and replication regulator; topBP1-interacting replication-stimulating protein; TopBP1-interacting, replication-stimulating protein; Treslin
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Gene Symbols: TICRR
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Molecular weight:
210,857 Da
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Basal Isoelectric point:
9
Predict pI for various phosphorylation states
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