G-alpha 11
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Belongs to the G-alpha family. G(q) subfamily. Expressed in testis. Note: This description may include information from UniProtKB.
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Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) |
Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM |
Cellular Component:
cytoplasm; heterotrimeric G-protein complex; membrane; plasma membrane
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Molecular Function:
alkylglycerophosphoethanolamine phosphodiesterase activity; enzyme regulator activity; G protein activity; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding; protein binding; protein-containing complex binding
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Biological Process:
action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cellular response to pH; cranial skeletal system development; developmental pigmentation; endothelin receptor signaling pathway; G protein-coupled receptor signaling pathway; glutamate receptor signaling pathway; heart development; ion channel modulating, G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; phospholipase C-activating dopamine receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of insulin secretion; regulation of blood pressure; regulation of melanocyte differentiation; signal transduction; skeletal system development
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Reference #:
P21278
(UniProtKB)
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Alt. Names/Synonyms: Dsk; Dsk7; E430025L19; G alpha-11; G-alpha 11; G-protein subunit alpha-11; Gna-11; Gna11; guanine nucleotide binding protein, alpha 11; Guanine nucleotide-binding protein subunit alpha-11
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Gene Symbols: Gna11
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Molecular weight:
42,024 Da
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Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Phospholipase Signaling
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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