G-alpha 11 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Belongs to the G-alpha family. G(q) subfamily. Expressed in testis. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cytoplasm; cytosol; heterotrimeric G-protein complex; membrane; plasma membrane; protein-containing complex
Molecular Function:  alkylglycerophosphoethanolamine phosphodiesterase activity; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding; protein-containing complex binding; type 2A serotonin receptor binding
Biological Process:  action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cellular response to pH; developmental pigmentation; G protein-coupled receptor signaling pathway; heart development; phospholipase C-activating dopamine receptor signaling pathway; protein heterotrimerization; regulation of melanocyte differentiation; signal transduction; skeletal system development
Reference #:  P21278 (UniProtKB)
Alt. Names/Synonyms: Dsk7; E430025L19; G alpha-11; G-protein subunit alpha-11; Gna-11; Gna11; guanine nucleotide binding protein, alpha 11; Guanine nucleotide-binding protein subunit alpha-11
Gene Symbols: Gna11
Molecular weight: 42,024 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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G-alpha 11

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene