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Fyn
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; SrcA subfamily; TK group |
| Chromosomal Location of mouse Ortholog: 10 B1|10 20.51 cM |
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Cellular Component:
actin filament; cell body; cell periphery; cytoplasm; cytosol; dendrite; endosome; extrinsic component of cytoplasmic side of plasma membrane; glial cell projection; glutamatergic synapse; membrane; membrane raft; mitochondrion; nucleus; perinuclear endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; Schaffer collateral - CA1 synapse
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Molecular Function:
alpha-tubulin binding; ATP binding; CD4 receptor binding; CD8 receptor binding; disordered domain specific binding; enzyme binding; ephrin receptor binding; G protein-coupled receptor binding; growth factor receptor binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphatidylinositol 3-kinase binding; phospholipase activator activity; phospholipase binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; scaffold protein binding; signaling receptor binding; T cell receptor binding; tau protein binding; transferase activity; transmembrane transporter binding; tubulin binding; type 5 metabotropic glutamate receptor binding
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Biological Process:
activated T cell proliferation; adaptive immune response; cell differentiation; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to glycine; cellular response to hydrogen peroxide; cellular response to L-glutamate; cellular response to platelet-derived growth factor stimulus; cellular response to transforming growth factor beta stimulus; dendrite morphogenesis; detection of mechanical stimulus involved in sensory perception of pain; forebrain development; heart process; I-kappaB kinase/NF-kappaB signaling; immune system process; innate immune response; intracellular signal transduction; modulation of chemical synaptic transmission; multicellular organism development; myelination; negative regulation of dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gene expression; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of neuron apoptotic process; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; neuron migration; neuron projection development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cysteine-type endopeptidase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein localization to nucleus; positive regulation of protein targeting to membrane; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein catabolic process; protein phosphorylation; protein ubiquitination; regulation of calcium ion import across plasma membrane; regulation of cell shape; regulation of glutamate receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; response to amyloid-beta; response to ethanol; response to singlet oxygen; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
P39688
(UniProtKB)
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Alt. Names/Synonyms: AI448320; AW552119; Fyn; Fyn proto-oncogene; MGC115870; p59-Fyn; Proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; Src Kinase p59; Tyrosine-protein kinase Fyn
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Gene Symbols: Fyn
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Molecular weight:
60,675 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Insulin Receptor Signaling
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Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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