JAK1 Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Note: This description may include information from UniProtKB.
Protein type: EC; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 4 C6|4 46.19 cM
Cellular Component:  cytoplasm; cytoskeleton; membrane; nucleus
Molecular Function:  ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding
Biological Process:  cellular response to interleukin-3; cellular response to interleukin-7; cytokine-mediated signaling pathway; enzyme linked receptor protein signaling pathway; interleukin-2-mediated signaling pathway; intracellular signal transduction; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of STAT cascade; protein phosphorylation; response to antibiotic; tyrosine phosphorylation of STAT protein
Reference #:  P52332 (UniProtKB)
Alt. Names/Synonyms: AA960307; BAP0; BAP004; C130039L05Rik; JAK-1; Jak1; Janus kinase 1; MGC37919; OTTMUSP00000008566; Tyrosine-protein kinase JAK1
Gene Symbols: Jak1
Molecular weight: 133,367 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling  |  Inhibition of Apoptosis  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene