APOB48R
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Expressed in peripheral blood leukocytes 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Receptor, misc. |
Chromosomal Location of mouse Ortholog: 7|7 F3 |
Cellular Component:
chylomicron; low-density lipoprotein particle; membrane; plasma membrane; very-low-density lipoprotein particle
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Molecular Function:
lipoprotein particle receptor activity; very-low-density lipoprotein particle receptor activity
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Biological Process:
cholesterol metabolic process; endocytosis; lipid metabolic process; lipid transport; steroid metabolic process; triglyceride metabolic process
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Reference #:
Q8VBT6
(UniProtKB)
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Alt. Names/Synonyms: AB48R; Apo; Apob; apoB-48R; Apob48r; APOBR; Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor
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Gene Symbols: Apobr
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Molecular weight:
102,705 Da
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Basal Isoelectric point:
4.33
Predict pI for various phosphorylation states
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