FRS2 Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 10|10 D2
Cellular Component:  cell-cell adherens junction; cell-cell junction; cytoplasm; membrane; plasma membrane
Molecular Function:  fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  activation of MAPK activity; anterior/posterior axis specification, embryo; cellular response to fibroblast growth factor stimulus; fibroblast growth factor receptor signaling pathway; forebrain development; gastrulation with mouth forming second; lens development in camera-type eye; lens fiber cell development; negative regulation of cardiac muscle cell differentiation; neuroblast proliferation; optic placode formation involved in camera-type eye formation; organ induction; positive regulation of vascular smooth muscle cell proliferation; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of apoptotic process; regulation of epithelial cell proliferation; regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; ventricular septum development
Reference #:  Q8C180 (UniProtKB)
Alt. Names/Synonyms: 4732458E18; C330018A15Rik; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; Frs; Frs2; FRS2-alpha; Frs2a; Frs2alpha; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
Gene Symbols: Frs2
Molecular weight: 56,794 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene