JNK1 a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  axon; basal dendrite; cytoplasm; cytosol; dendrite cytoplasm; mitochondrion; neuron projection; nucleus; perikaryon; podosome; vesicle
Molecular Function:  ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; kinesin binding; MAP kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transferase activity
Biological Process:  cellular response to amino acid starvation; cellular response to cadmium ion; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cellular response to nitric oxide; cellular response to organic substance; cellular response to reactive oxygen species; dendrite morphogenesis; determination of dorsal identity; inflammatory response; intracellular signal transduction; JNK cascade; JUN phosphorylation; negative regulation of apoptotic process; negative regulation of protein binding; neuron development; neuron migration; neuron projection development; neuronal stem cell population maintenance; ossification; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell migration; positive regulation of cyclase activity; positive regulation of deacetylase activity; positive regulation of determination of dorsal identity; positive regulation of DNA replication; positive regulation of gene expression; positive regulation of glial cell apoptotic process; positive regulation of microtubule polymerization; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of neuron migration; positive regulation of podosome assembly; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; positive regulation of transcription factor catabolic process; programmed necrotic cell death; protein localization to tricellular tight junction; protein phosphorylation; regulation of centrosome cycle; regulation of circadian rhythm; regulation of DNA replication origin binding; regulation of gene expression; regulation of neuron differentiation; regulation of protein localization; regulation of transcription, DNA-templated; response to cadmium ion; response to heat; response to hydrogen peroxide; response to mechanical stimulus; response to osmotic stress; response to UV; rhythmic process; signal transduction; stress-activated MAPK cascade; type B pancreatic cell apoptotic process
Reference #:  Q91Y86 (UniProtKB)
Alt. Names/Synonyms: AI849689; c-Jun N-terminal kinase 1; JNK; Jnk1; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; Mapk8; mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08; OTTMUSP00000019790; Prkm8; protein kinase mitogen-activated 8; SAPK1; Stress-activated protein kinase JNK1
Gene Symbols: Mapk8
Molecular weight: 44,229 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene