FGFR4 Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; FGFR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of mouse Ortholog: 13 B1|13 29.8 cM
Cellular Component:  cell-cell junction; endoplasmic reticulum; endosome; Golgi apparatus; membrane; plasma membrane; receptor complex; transport vesicle
Molecular Function:  ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; heparin binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  alveolar secondary septum development; cell migration; cholesterol homeostasis; fibroblast growth factor receptor signaling pathway; glucose homeostasis; lung development; multicellular organism development; negative regulation of fibroblast growth factor production; negative regulation of gene expression; organ induction; peptidyl-tyrosine phosphorylation; phosphate ion homeostasis; phosphorylation; positive regulation of catalytic activity; positive regulation of cell population proliferation; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of parathyroid hormone secretion; positive regulation of proteolysis; protein autophosphorylation; protein phosphorylation; regulation of bile acid biosynthetic process; regulation of extracellular matrix disassembly; regulation of lipid metabolic process; regulation of phosphate transport; regulation of phosphorus metabolic process; transmembrane receptor protein tyrosine kinase signaling pathway; vitamin D3 metabolic process
Reference #:  Q03142 (UniProtKB)
Alt. Names/Synonyms: CD334; CTLA-2-beta protein; Fgfr-; FGFR-4; Fgfr4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; Mpk-11; Protein-tyrosine kinase receptor MPK-11
Gene Symbols: Fgfr4
Molecular weight: 88,661 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene