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UBE2A
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Belongs to the ubiquitin-conjugating enzyme family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; Ubiquitin conjugating system |
| Chromosomal Location of mouse Ortholog: X|X A3.3 |
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Cellular Component:
chromatin; HULC complex; XY body
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Molecular Function:
ATP binding; histone ubiquitin ligase activity; nucleotide binding; protein binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
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Biological Process:
blastocyst hatching; DNA damage response; DNA repair; G2/M transition of mitotic cell cycle; histone H2A ubiquitination; histone ubiquitination; in utero embryonic development; maternal process involved in female pregnancy; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; response to UV
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Reference #:
Q9Z255
(UniProtKB)
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Alt. Names/Synonyms: E2 ubiquitin-conjugating enzyme A; HHR; HHR6A; HR6A; mHR6A; OTTMUSP00000018586; RAD6 homolog A; Rad6a; Ube2a; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae); ubiquitin-conjugating enzyme HR6A; Ubiquitin-protein ligase A
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Gene Symbols: Ube2a
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Molecular weight:
17,315 Da
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Basal Isoelectric point:
5.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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