SIRT3
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Belongs to the sirtuin family. Class I subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial |
Chromosomal Location of human Ortholog: 11p15.5 |
Cellular Component:
mitochondrial matrix; mitochondrion; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
enzyme binding; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD+-protein ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent protein deacetylase activity; protein binding; sequence-specific DNA binding; zinc ion binding
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Biological Process:
aerobic respiration; chromatin remodeling; negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; peptidyl-lysine deacetylation; positive regulation of catalase activity; positive regulation of ceramide biosynthetic process; positive regulation of insulin secretion; positive regulation of superoxide dismutase activity; protein deacetylation
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Reference #:
Q9NTG7
(UniProtKB)
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Alt. Names/Synonyms: hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; Regulatory protein SIR2 homolog 3; silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIR2L3; SIR3; SIRT3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3; sirtuin type 3
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Gene Symbols: SIRT3
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Molecular weight:
43,573 Da
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Basal Isoelectric point:
8.98
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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