FGFR2 Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; FGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  cell cortex; cell surface; cytoplasm; cytoplasmic vesicle; excitatory synapse; extracellular region; Golgi apparatus; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  ATP binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  angiogenesis; animal organ morphogenesis; apoptotic process; axonogenesis; bone development; bone mineralization; bone morphogenesis; branch elongation involved in salivary gland morphogenesis; branching involved in labyrinthine layer morphogenesis; branching involved in prostate gland morphogenesis; branching involved in salivary gland morphogenesis; branching morphogenesis of a nerve; bud elongation involved in lung branching; cell fate commitment; cell-cell signaling; coronal suture morphogenesis; digestive tract development; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic organ development; embryonic organ morphogenesis; embryonic pattern specification; endodermal digestive tract morphogenesis; epidermis morphogenesis; epithelial cell differentiation; epithelial cell proliferation involved in salivary gland morphogenesis; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; gland morphogenesis; hair follicle morphogenesis; in utero embryonic development; inner ear morphogenesis; lacrimal gland development; lateral sprouting from an epithelium; lens fiber cell development; limb bud formation; lung alveolus development; lung development; lung lobe morphogenesis; lung-associated mesenchyme development; mammary gland bud formation; membranous septum morphogenesis; mesenchymal cell differentiation; mesenchymal cell differentiation involved in lung development; mesenchymal cell proliferation involved in lung development; midbrain development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of mitotic nuclear division; negative regulation of transcription by RNA polymerase II; neuromuscular junction development; odontogenesis; orbitofrontal cortex development; organ growth; otic vesicle formation; outflow tract septum morphogenesis; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phospholipase activity; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of Wnt signaling pathway; post-embryonic development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; prostate gland morphogenesis; protein autophosphorylation; protein phosphorylation; pyramidal neuron development; regulation of cell proliferation; regulation of epithelial cell proliferation; regulation of ERK1 and ERK2 cascade; regulation of morphogenesis of a branching structure; regulation of smooth muscle cell differentiation; regulation of smoothened signaling pathway; reproductive structure development; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; synaptic vesicle transport; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular zone neuroblast division
Reference #:  P21803 (UniProtKB)
Alt. Names/Synonyms: AU043015; AW556123; Bek; CD332; Ect1; Fgfr; Fgfr-; FGFR-2; Fgfr-7; Fgfr2; Fgfr7; Fibroblast growth factor receptor 2; Keratinocyte growth factor receptor; KGFR; KGFRTr; MGC102519; svs
Gene Symbols: Fgfr2
Molecular weight: 91,984 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FGFR2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene