Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. 19 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; FGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Cellular Component: cytoplasm; cytoplasmic vesicle; integral component of membrane; integral component of plasma membrane; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function: ATP binding; cell adhesion molecule binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; receptor-receptor interaction; SH2 domain binding; signaling receptor binding; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: angiogenesis; auditory receptor cell development; blood vessel morphogenesis; brain development; branching involved in salivary gland morphogenesis; cell maturation; central nervous system neuron development; chondrocyte differentiation; ear development; embryonic limb morphogenesis; fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; generation of neurons; in utero embryonic development; inner ear morphogenesis; lung development; lung-associated mesenchyme development; mesenchymal cell differentiation; midbrain development; middle ear morphogenesis; motogenic signaling involved in postnatal olfactory bulb interneuron migration; negative regulation of fibroblast growth factor production; negative regulation of gene expression; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; neuron projection development; orbitofrontal cortex development; organ induction; outer ear morphogenesis; paraxial mesoderm development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of fibroblast migration; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of mitotic cell cycle DNA replication; positive regulation of neuron differentiation; positive regulation of neuron projection development; positive regulation of parathyroid hormone secretion; positive regulation of phospholipase C activity; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial cell proliferation; protein autophosphorylation; protein phosphorylation; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of cell proliferation; regulation of extrinsic apoptotic signaling pathway in absence of ligand; regulation of gene expression; regulation of lateral mesodermal cell fate specification; regulation of phosphate transport; regulation of phosphorus metabolic process; regulation of sensory perception of pain; regulation of stem cell proliferation; salivary gland morphogenesis; sensory perception of sound; stem cell population maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development; vasculogenesis involved in coronary vascular morphogenesis; ventricular zone neuroblast division; vitamin D3 metabolic process