FCGR2B Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Oncoprotein
Chromosomal Location of mouse Ortholog: 1 H3|1 78.02 cM
Cellular Component:  cell body; cell surface; cytoplasm; cytoskeleton; dendritic spine; external side of plasma membrane; extracellular region; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; recycling endosome
Molecular Function:  amyloid-beta binding; IgG binding; immunoglobulin binding; low-affinity IgG receptor activity; protein binding; protein-containing complex binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor signaling pathway; cellular response to amyloid-beta; cellular response to molecule of bacterial origin; cerebellum development; defense response; dendrite development; endocytic recycling; Fc-gamma receptor signaling pathway involved in phagocytosis; immune complex clearance; immunoglobulin mediated immune response; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of immune response; negative regulation of immunoglobulin production; negative regulation of inflammatory response to antigenic stimulus; negative regulation of interleukin-10 production; negative regulation of neutrophil apoptotic process; negative regulation of phagocytosis; negative regulation of type I hypersensitivity; phagocytosis, engulfment; positive regulation of DNA-binding transcription factor activity; positive regulation of JNK cascade; positive regulation of neuron death; positive regulation of phagocytosis; positive regulation of response to endoplasmic reticulum stress; receptor-mediated endocytosis; regulation of dendritic spine maintenance; regulation of long-term neuronal synaptic plasticity; response to bacterium
Reference #:  P08101 (UniProtKB)
Alt. Names/Synonyms: AI528646; CD32; F630109E10Rik; Fc gamma receptor IIB; Fc gamma RIIB; Fc receptor, IgG, low affinity IIb; Fc-gamma RII; Fc-gamma-RII; Fc-gamma-RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; FcgammaRIIB; Fcgr; Fcgr2; Fcgr2a; Fcgr2b; FcgRII; Fcr-; Fcr-2; Fcr-3; FcRII; IgG Fc receptor II beta; Low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; Ly-m2; Ly-m20; LyM-; LyM-1; Lymphocyte antigen 17; OTTMUSP00000024374; OTTMUSP00000024375
Gene Symbols: Fcgr2
Molecular weight: 36,695 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene