PTEN Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. Belongs to the PTEN phosphatase protein family. Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; EC; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Phosphatase, lipid; Tumor suppressor
Chromosomal Location of Human Ortholog: 19 C1|19 28.14 cM
Cellular Component:  apical plasma membrane; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; mitochondrion; myelin sheath adaxonal region; neuron projection; nucleoplasm; nucleus; plasma membrane; postsynaptic cytosol; postsynaptic membrane; Schmidt-Lanterman incisure
Molecular Function:  anaphase-promoting complex binding; enzyme binding; hydrolase activity; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; ionotropic glutamate receptor binding; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein serine/threonine phosphatase activity; protein tyrosine kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; ubiquitin-specific protease binding
Biological Process:  adult behavior; angiogenesis; apoptotic process; brain morphogenesis; canonical Wnt signaling pathway; cardiac muscle tissue development; cell migration; cellular response to decreased oxygen levels; cellular response to electrical stimulus; cellular response to ethanol; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to insulin-like growth factor stimulus; cellular response to leptin stimulus; central nervous system development; central nervous system myelin maintenance; central nervous system neuron axonogenesis; dendritic spine morphogenesis; dentate gyrus development; dephosphorylation; endothelial cell migration; forebrain morphogenesis; heart development; inositol phosphate dephosphorylation; learning or memory; lipid metabolic process; locomotor rhythm; locomotory behavior; long-term synaptic depression; long-term synaptic potentiation; male mating behavior; maternal behavior; memory; multicellular organismal response to stress; negative regulation of apoptotic process; negative regulation of axon regeneration; negative regulation of axonogenesis; negative regulation of cardiac muscle cell proliferation; negative regulation of cell aging; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of dendritic spine morphogenesis; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of excitatory postsynaptic potential; negative regulation of focal adhesion assembly; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of keratinocyte migration; negative regulation of myelination; negative regulation of organ growth; negative regulation of phagocytosis; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of ribosome biogenesis; negative regulation of signaling receptor activity; negative regulation of synaptic vesicle clustering; negative regulation of vascular smooth muscle cell proliferation; negative regulation of wound healing, spreading of epidermal cells; nervous system development; neuron projection development; neuron-neuron synaptic transmission; phosphatidylinositol dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of TRAIL-activated apoptotic signaling pathway; positive regulation of ubiquitin protein ligase activity; positive regulation of ubiquitin-dependent protein catabolic process; postsynaptic density assembly; prepulse inhibition; presynaptic membrane assembly; prostate gland growth; protein dephosphorylation; protein kinase B signaling; protein stabilization; regulation of axon regeneration; regulation of B cell apoptotic process; regulation of cell cycle; regulation of cellular component size; regulation of cellular localization; regulation of myeloid cell apoptotic process; regulation of neuron projection development; regulation of protein stability; regulation of synaptic transmission, GABAergic; rhythmic synaptic transmission; social behavior; synapse assembly; synapse maturation
Reference #:  O08586 (UniProtKB)
Alt. Names/Synonyms: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MGC183880; mitochondrial PTENalpha; MMAC; Mmac1; Mutated in multiple advanced cancers 1; OTTMUSP00000023423; Phosphatase and tensin homolog; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Pten; PTENbeta; PTENepsilon; TEP; TEP1
Gene Symbols: Pten
Molecular weight: 47,152 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA