ORC6L Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. Belongs to the ORC6 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of human Ortholog: 16q11.2
Cellular Component:  fibrillar center; nucleoplasm; nucleus; origin recognition complex
Molecular Function:  protein binding
Biological Process:  DNA replication; G1/S transition of mitotic cell cycle; negative regulation of cell division
Disease: Meier-gorlin Syndrome 3
Reference #:  Q9Y5N6 (UniProtKB)
Alt. Names/Synonyms: ORC6; ORC6L; Origin recognition complex subunit 6; origin recognition complex, subunit 6 homolog-like; origin recognition complex, subunit 6 like (yeast)
Gene Symbols: ORC6
Molecular weight: 28,107 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ORC6L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene