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HePTP
Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Expressed exclusively in thymus and spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) |
| Chromosomal Location of rat Ortholog: 13q13 |
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Cellular Component:
cytoplasm; cytoplasmic side of plasma membrane; cytosol; microtubule cytoskeleton; mitotic spindle
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Molecular Function:
protein tyrosine phosphatase activity
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Biological Process:
protein dephosphorylation
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Reference #:
P49445
(UniProtKB)
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Alt. Names/Synonyms: Hematopoietic protein-tyrosine phosphatase; HEPTP; Lcptp; protein tyrosine phosphatase, non-receptor type 7; Protein-tyrosine phosphatase LC-PTP; protein-tyrosine phosphatase, non-receptor type 7; PTN7; Ptpn7; Tyrosine-protein phosphatase non-receptor type 7
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Gene Symbols: Ptpn7
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Molecular weight:
40,314 Da
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Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
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