HePTP a non-receptor protein-tyrosine phosphatase. Preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. Its noncatalytic N-terminus can interact with MAP kinases and suppress the MAP kinase activities. Shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Three alternatively spliced transcript variants of this gene, which encode two distinct isoforms, are reported. May play a role in the regulation of lymphocyte development. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 13q13
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol
Molecular Function:  protein tyrosine phosphatase activity
Biological Process:  protein amino acid dephosphorylation
Reference #:  P49445 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic protein-tyrosine phosphatase; HEPTP; Lcptp; protein tyrosine phosphatase, non-receptor type 7; Protein-tyrosine phosphatase LC-PTP; protein-tyrosine phosphatase, non-receptor type 7; PTN7; Ptpn7; Tyrosine-protein phosphatase non-receptor type 7
Gene Symbols: Ptpn7
Molecular weight: 40,314 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

HePTP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene