HePTP Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Expressed exclusively in thymus and spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 13q13
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol
Molecular Function:  protein tyrosine phosphatase activity
Biological Process:  peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  P49445 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic protein-tyrosine phosphatase; HEPTP; Lcptp; protein tyrosine phosphatase, non-receptor type 7; Protein-tyrosine phosphatase LC-PTP; protein-tyrosine phosphatase, non-receptor type 7; PTN7; Ptpn7; Tyrosine-protein phosphatase non-receptor type 7
Gene Symbols: Ptpn7
Molecular weight: 40,314 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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HePTP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene