XPNPEP2 Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. Belongs to the peptidase M24B family. Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, GPI anchor; Protease
Chromosomal Location of human Ortholog: Xq26.1
Cellular Component:  anchored component of membrane; extracellular exosome; extracellular region; membrane; plasma membrane
Molecular Function:  aminopeptidase activity; metal ion binding; metalloaminopeptidase activity
Biological Process:  proteolysis
Disease: Angioedema Induced By Ace Inhibitors, Susceptibility To
Reference #:  O43895 (UniProtKB)
Alt. Names/Synonyms: AEACEI; Aminoacylproline aminopeptidase; APP2; mAmP; Membrane-bound aminopeptidase P; Membrane-bound AmP; Membrane-bound APP; X-Pro aminopeptidase 2; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; X-prolyl aminopeptidase 2; Xaa-Pro aminopeptidase 2; XPNPEP2; XPP2
Gene Symbols: XPNPEP2
Molecular weight: 75,625 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene