PTP1B Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 H3
Cellular Component:  cytoplasm; cytoplasmic side of endoplasmic reticulum membrane; cytoplasmic vesicle; cytosol; early endosome; endoplasmic reticulum; membrane; protein-containing complex; sorting endosome
Molecular Function:  enzyme binding; ephrin receptor binding; hydrolase activity; insulin receptor binding; phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding; protein phosphatase 2A binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; zinc ion binding
Biological Process:  actin cytoskeleton reorganization; activation of JUN kinase activity; dephosphorylation; endoplasmic reticulum unfolded protein response; insulin receptor signaling pathway; IRE1-mediated unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAP kinase activity; negative regulation of PERK-mediated unfolded protein response; negative regulation of vascular endothelial growth factor receptor signaling pathway; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of protein tyrosine kinase activity; positive regulation of receptor catabolic process; protein dephosphorylation; regulation of endocytosis; regulation of hepatocyte growth factor receptor signaling pathway; regulation of insulin receptor signaling pathway; regulation of intracellular protein transport; regulation of signal transduction; response to endoplasmic reticulum stress
Reference #:  P35821 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000017024; protein tyrosine phosphatase, non-receptor type 1; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; PTP1B; Ptpn1; Tyrosine-protein phosphatase non-receptor type 1
Gene Symbols: Ptpn1
Molecular weight: 49,593 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene