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WDR35
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 12|12 A1.1 |
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Cellular Component:
axoneme; cell projection; centrosome; ciliary basal body; cilium; cytoplasm; cytoskeleton; intraciliary transport particle A
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Biological Process:
cell projection organization; cellular response to leukemia inhibitory factor; cellular response to tumor necrosis factor; cilium assembly; intraciliary retrograde transport; intraciliary transport; negative regulation of gene expression; negative regulation of nitric oxide biosynthetic process; positive regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of vasoconstriction; protein localization to cilium
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Reference #:
Q8BND3
(UniProtKB)
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Alt. Names/Synonyms: 4930459M12Rik; 4931430C06; KIAA1336; mKIAA1336; WD repeat domain 35; WD repeat-containing protein 35; Wdr35
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Gene Symbols: Wdr35
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Molecular weight:
133,991 Da
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Basal Isoelectric point:
5.96
Predict pI for various phosphorylation states
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