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HDAC5
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Belongs to the histone deacetylase family. HD type 2 subfamily. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deacetylase; EC 3.5.1.98; Hydrolase |
| Chromosomal Location of mouse Ortholog: 11|11 D |
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Cellular Component:
axonal growth cone; chromatin; cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nuclear body; nuclear speck; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex
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Molecular Function:
chromatin binding; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase activity; histone deacetylase binding; hydrolase activity; identical protein binding; metal ion binding; protein binding; protein kinase binding; protein kinase C binding; protein lysine deacetylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription cis-regulatory region binding; transcription corepressor activity; transcription corepressor binding
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Biological Process:
B cell activation; B cell differentiation; cellular response to fluid shear stress; chromatin organization; epigenetic regulation of gene expression; heart development; histone deacetylation; inflammatory response; multicellular organismal response to stress; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of myotube differentiation; negative regulation of osteoblast differentiation; negative regulation of striated muscle tissue development; negative regulation of transcription by RNA polymerase II; nervous system development; osteoblast development; osteoblast differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of myotube differentiation; regulation of protein binding; regulation of skeletal muscle fiber development; regulation of skeletal muscle fiber differentiation; renal tubule morphogenesis; response to cocaine; response to xenobiotic stimulus
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Reference #:
Q9Z2V6
(UniProtKB)
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Alt. Names/Synonyms: AI426555; HD5; Hdac4; Hdac5; histone deacetylase 4; Histone deacetylase 5; Histone deacetylase mHDA1; mHDA; mHDA1; mKIAA0600; OTTMUSP00000002428
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Gene Symbols: Hdac5
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Molecular weight:
120,942 Da
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Basal Isoelectric point:
5.81
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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NF-kB Signaling
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Protein Acetylation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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