HDAC5 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Belongs to the histone deacetylase family. HD type 2 subfamily. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Hydrolase
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nuclear body; nuclear chromatin; nuclear speck; nucleus; protein-containing complex; RNA polymerase II transcription repressor complex
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase activity; histone deacetylase binding; hydrolase activity; metal ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); protein binding; protein deacetylase activity; protein kinase binding; protein kinase C binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription corepressor binding; RNA polymerase II transcription factor binding; transcription corepressor activity; transcription factor binding
Biological Process:  B cell activation; B cell differentiation; cellular response to fluid shear stress; chromatin organization; heart development; histone deacetylation; inflammatory response; multicellular organismal response to stress; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of gene expression; negative regulation of myotube differentiation; negative regulation of osteoblast differentiation; negative regulation of striated muscle tissue development; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nervous system development; osteoblast development; positive regulation of DNA-binding transcription factor activity; positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; protein deacetylation; regulation of gene expression, epigenetic; regulation of myotube differentiation; regulation of protein binding; regulation of skeletal muscle fiber development; regulation of striated muscle cell differentiation; renal tubule morphogenesis; response to cocaine; response to drug
Reference #:  Q9Z2V6 (UniProtKB)
Alt. Names/Synonyms: AI426555; HD5; Hdac4; Hdac5; histone deacetylase 4; Histone deacetylase 5; Histone deacetylase mHDA1; mHDA; mHDA1; mKIAA0600; OTTMUSP00000002428
Gene Symbols: Hdac5
Molecular weight: 120,942 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene