HCRTR1 Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; orexin receptor activity; peptide hormone binding; protein binding
Biological Process:  feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; regulation of cytosolic calcium ion concentration; signal transduction
Reference #:  P58307 (UniProtKB)
Alt. Names/Synonyms: Hcrtr1; hypocretin (orexin) receptor 1; Hypocretin receptor type 1; MGC141357; Orexin receptor type 1; OTTMUSP00000009912; Ox-1-R; Ox1-R; Ox1R
Gene Symbols: Hcrtr1
Molecular weight: 46,781 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene