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HCRTR1
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 1p35.2 |
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Cellular Component:
plasma membrane; synapse
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Molecular Function:
G protein-coupled receptor activity; orexin receptor activity; peptide hormone binding
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Biological Process:
chemical synaptic transmission; feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; regulation of cytosolic calcium ion concentration
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Reference #:
O43613
(UniProtKB)
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Alt. Names/Synonyms: HCRTR1; hypocretin (orexin) receptor 1; hypocretin receptor 1; Hypocretin receptor type 1; hypocretin receptor-1; orexin receptor 1; Orexin receptor type 1; orexin receptor-1; Ox-1-R; Ox1-R; Ox1R
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Gene Symbols: HCRTR1
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Molecular weight:
47,536 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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