HCRTR1 Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 1p35.2
Cellular Component:  plasma membrane; synapse
Molecular Function:  G protein-coupled receptor activity; orexin receptor activity; peptide hormone binding
Biological Process:  chemical synaptic transmission; feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; regulation of cytosolic calcium ion concentration
Reference #:  O43613 (UniProtKB)
Alt. Names/Synonyms: HCRTR1; hypocretin (orexin) receptor 1; hypocretin receptor 1; Hypocretin receptor type 1; hypocretin receptor-1; orexin receptor 1; Orexin receptor type 1; orexin receptor-1; Ox-1-R; Ox1-R; Ox1R
Gene Symbols: HCRTR1
Molecular weight: 47,536 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene