RAD9A Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'- Belongs to the rad9 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  checkpoint clamp complex; cytoplasm; nucleoplasm; nucleus
Molecular Function:  3'-5' exonuclease activity; enzyme binding; exodeoxyribonuclease III activity; exonuclease activity; histone deacetylase binding; hydrolase activity; nuclease activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process:  cellular response to DNA damage stimulus; cellular response to ionizing radiation; DNA damage checkpoint; DNA repair; intra-S DNA damage checkpoint; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; response to radiation
Reference #:  Q9Z0F6 (UniProtKB)
Alt. Names/Synonyms: Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; mRAD9; Rad9; RAD9 homolog (S. pombe); Rad9-like protein; Rad9a
Gene Symbols: Rad9a
Molecular weight: 42,059 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
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RAD9A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene