SP110 Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding
Biological Process:  regulation of transcription by RNA polymerase II; viral process
Disease: Hepatic Venoocclusive Disease With Immunodeficiency; Mycobacterium Tuberculosis, Susceptibility To
Reference #:  Q9HB58 (UniProtKB)
Alt. Names/Synonyms: FLJ22835; IFI41; IFI75; interferon-induced protein 41, 30kD; Interferon-induced protein 41/75; interferon-induced protein 75, 52kD; IPR1; phosphoprotein 41; phosphoprotein 75; SP110; Sp110 nuclear body protein; Speckled 110 kDa; Transcriptional coactivator Sp110; VODI
Gene Symbols: SP110
Molecular weight: 78,396 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein