Radixin a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9|9 A5.3
Cellular Component:  apical part of cell; apical plasma membrane; cell periphery; cell projection; cell tip; cell-cell adherens junction; cleavage furrow; cortical actin cytoskeleton; cytoplasm; cytoskeleton; filopodium; lamellipodium; membrane; microvillus; midbody; plasma membrane; ruffle; stereocilium; T-tubule
Molecular Function:  actin binding; ATPase binding; cytoskeletal protein binding; protein binding; protein domain specific binding; protein homodimerization activity
Biological Process:  actin filament capping; apical protein localization; barbed-end actin filament capping; cellular response to thyroid hormone stimulus; establishment of endothelial barrier; establishment of protein localization; microvillus assembly; negative regulation of adherens junction organization; negative regulation of cell size; negative regulation of GTPase activity; negative regulation of homotypic cell-cell adhesion; positive regulation of cell migration; positive regulation of cellular protein catabolic process; positive regulation of early endosome to late endosome transport; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of protein localization to early endosome; protein localization to plasma membrane; regulation of actin filament bundle assembly; regulation of cell shape; regulation of cell size; regulation of GTPase activity; regulation of organelle assembly; regulation of ruffle assembly
Reference #:  P26043 (UniProtKB)
Alt. Names/Synonyms: AA516625; ESP10; RADI; Radixin; Rdx
Gene Symbols: Rdx
Molecular weight: 68,543 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene