GMPR
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. Note: This description may include information from UniProtKB.
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Protein type: EC 1.7.1.7; Nucleotide Metabolism - purine; Oxidoreductase |
Chromosomal Location of mouse Ortholog: 13|13 A5 |
Cellular Component:
GMP reductase complex
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Molecular Function:
catalytic activity; GMP reductase activity; metal ion binding; oxidoreductase activity
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Biological Process:
IMP salvage; nucleotide metabolic process; purine nucleobase metabolic process
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Reference #:
Q9DCZ1
(UniProtKB)
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Alt. Names/Synonyms: 2310004P21Rik; AV028449; GMP reductase 1; Gmpr; GMPR 1; Gmpr1; Guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase; Guanosine monophosphate reductase 1; OTTMUSP00000027400
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Gene Symbols: Gmpr
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Molecular weight:
37,482 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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