GMPR Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Oxidoreductase
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component:  cytosol; GMP reductase complex
Molecular Function:  metal ion binding
Biological Process:  oxidation-reduction process; purine nucleobase metabolic process; purine-containing compound salvage; response to cold
Reference #:  P36959 (UniProtKB)
Alt. Names/Synonyms: GMP reductase 1; GMPR; GMPR 1; GMPR1; guanine monophosphate reductase; Guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase; Guanosine monophosphate reductase 1
Gene Symbols: GMPR
Molecular weight: 37,419 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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