XPR1 Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Belongs to the SYG1 (TC 2.A.94) family. Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1 G3|1 66.49 cM
Cellular Component:  Golgi apparatus; integral component of membrane; intrinsic component of plasma membrane; membrane; plasma membrane
Molecular Function:  efflux transmembrane transporter activity; inositol hexakisphosphate binding; phosphate ion transmembrane transporter activity; virus receptor activity
Biological Process:  cellular phosphate ion homeostasis; cellular response to phosphate starvation; phosphate ion transmembrane transport; phosphate ion transport; response to virus
Reference #:  Q9Z0U0 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000025641; Protein SYG1 homolog; receptor for MCF virus 1; Rmc; Rmc-; Rmc-1; Rmc1; suppressor of yeast G<a> deletion; susceptibility to xenotropic virus; Sxv; Syg; Syg1; xenotropic and polytropic murine leukemia virus receptor; Xenotropic and polytropic retrovirus receptor 1; xenotropic and polytropic retrovirus receptor 1 homolog; Xpr1; XR
Gene Symbols: Xpr1
Molecular weight: 81,751 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
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XPR1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene