XPR1 Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Belongs to the SYG1 (TC 2.A.94) family. Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component:  integral component of membrane; intrinsic component of plasma membrane
Molecular Function:  efflux transmembrane transporter activity; G protein-coupled receptor activity; inositol hexakisphosphate binding; phosphate ion transmembrane transporter activity; signaling receptor activity; transmembrane signaling receptor activity; virus receptor activity
Biological Process:  cellular phosphate ion homeostasis; G protein-coupled receptor signaling pathway; phosphate ion transmembrane transport; response to virus; viral entry into host cell
Disease: Basal Ganglia Calcification, Idiopathic, 6
Reference #:  Q9UBH6 (UniProtKB)
Alt. Names/Synonyms: FLJ90308; IBGC6; Protein SYG1 homolog; SLC53A1; solute carrier family 53 (phosphate exporter), member 1; SYG1; X-receptor; X3; Xenotropic and polytropic murine leukemia virus receptor X3; xenotropic and polytropic retrovirus receptor; Xenotropic and polytropic retrovirus receptor 1; XPR1; XR
Gene Symbols: XPR1
Molecular weight: 81,535 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
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XPR1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein