Ret a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ret family; TK group
Chromosomal Location of Human Ortholog: 6 F1|6 55.86 cM
Cellular Component:  axon; cytosol; dendrite; early endosome; endosome; endosome membrane; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; membrane raft; neuronal cell body; plasma membrane; plasma membrane protein complex; receptor complex
Molecular Function:  ATP binding; calcium ion binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of MAPK activity; anatomical structure morphogenesis; cell adhesion; cell differentiation; cellular response to retinoic acid; embryonic epithelial tube formation; enteric nervous system development; glial cell-derived neurotrophic factor receptor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; innervation; MAPK cascade; membrane protein proteolysis; nervous system development; neural crest cell migration; neurogenesis; neuron cell-cell adhesion; neuron differentiation; neuron maturation; Peyer's patch morphogenesis; phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of metanephric glomerulus development; positive regulation of neuron maturation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of protein kinase B signaling; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of axonogenesis; regulation of cell adhesion; response to pain; transmembrane receptor protein tyrosine kinase signaling pathway; ureter maturation; ureteric bud development
Reference #:  P35546 (UniProtKB)
Alt. Names/Synonyms: c-Ret; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; Ret; ret proto-oncogene; RET51; RET9
Gene Symbols: Ret
Molecular weight: 123,874 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene