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Ret
a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ret family; TK group |
| Chromosomal Location of Human Ortholog: 6 F1|6 55.86 cM |
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Cellular Component:
axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endosome; endosome membrane; integral component of membrane; integral component of plasma membrane; intracellular membrane-bound organelle; membrane; membrane raft; plasma membrane; plasma membrane protein complex; receptor complex
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Molecular Function:
ATP binding; calcium ion binding; kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of MAPK activity; anatomical structure morphogenesis; cell adhesion; cell differentiation; cellular response to retinoic acid; embryonic epithelial tube formation; enteric nervous system development; homophilic cell adhesion; MAPK cascade; membrane protein proteolysis; multicellular organism development; negative regulation of apoptosis; negative regulation of signal transduction; nervous system development; neural crest cell migration; neuron adhesion; neuron differentiation; neuron maturation; phosphorylation; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of cell size; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of metanephric glomerulus development; positive regulation of neuron maturation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of protein kinase B signaling; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cell adhesion; regulation of peptidyl-serine phosphorylation of STAT protein; response to pain; transmembrane receptor protein tyrosine kinase signaling pathway; ureteric bud development
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Reference #:
P35546
(UniProtKB)
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Alt. Names/Synonyms: c-Ret; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; Ret; ret proto-oncogene; RET51; RET9
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Gene Symbols: Ret
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Molecular weight:
123,874 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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